Applied research within the health laboratory services network is a requirement aimed at solving local public health problems. Research innovations have the potential of delivering cost effective, reliable, accurate and quality diagnostic services. Applied research and implementation science in the Uganda National Health Laboratory Network is limited. There is no coordinated mechanism to prioritize research and development through adequate funding, training, coordination and management of the research agenda. Efforts are underway to streamline data collection through the national health laboratory information system and to promote the research agenda across the laboratory network. This policy is intended to address the gaps identified. Specific strategies such as the training of human resources, recruitment of higher-level cadres and infrastructure development will boost applied research and implementation science at all levels of the health laboratory network.