National Health Laboratory Services and Diagnostics (NHLDS) provides two (2) core functions: coordination of laboratory services across all tiers of the health system and provision of specialized reference laboratory testing services. These services are offered by state-of-the-art national reference laboratories, including the Central Public Health Laboratories (CPHL), the National Microbiology Reference Laboratories (NMRL), the Central Emergency Response and Surveillance Laboratory (CERSL), and the National TB Reference Laboratory (NTRL), all of which are internationally accredited.
The National Biorepository was established in April 2017 with a primary objective of storing remnant samples from national health programs in a high-quality, retrievable manner and making them available for ethically approved research.
National Biorepository offers services for specimen acquisition, reception, processing, storage, distribution, data and information protection, governance, and documentation.
We manage specimens from National reference laboratories, Government & private hospitals, and Research organizations both within and outside the country. Specimens are stored for short- or long-term, depending on the agreed-upon terms in the MoU. Specimens are shipped through the National Sample Transport and Results Network, self-deliveries, and courier companies.
Dried blood Spot specimen collected from the Early Infant Diagnosis Program and the HIV viral load monitoring program. Specimens have a uniquely nationally representative sample with characteristic data variables including gender, age at collection, geographic location (district), antiretroviral therapy (ART) regimen, and date of ART initiation, HIV-1 confirmed diagnosis, HIV-1 viral load quantification, and duration on the ART regimen.
Plasma specimens are collected from the HIV viral load monitoring program. Specimens constitute a uniquely nationally representative sample with characteristic data variables, including gender, age at collection, geographic location (district), antiretroviral therapy (ART) regimen, date of ART initiation, HIV-1 viral load quantification, and duration on the ART regimen.
We store microbiology isolates collected from Regional Referral Hospitals, mostly from patient samples to aid clinical management. These include Escherichia coli, Klebsiella species, Enterococcus species, Streptococcus species, Staphylococcus species, Neisseria meningitidis, and Proteus species, among others.
Plasma specimens are collected from the Hepatitis B viral load monitoring program. Specimens are uniquely nationally representative with characteristic data variables including the gender, age at collection, geographic location (district) and Hepatitis B viral load quantification.
We store Dried Blood Spots samples that have been characterized with sickle cell trait genotypes, i.e., Hb AA – No sickle cell disease, Hb AS – Sickle cell trait carrier, and Hb SS – Sickle cell disease. These samples are nationally representative. These samples have been collected from the neonatal screening program and can be further analyzed for hereditary disorders.
We store confirmed SARS-CoV-2 specimens uniquely collected across the whole country of Uganda.
The first Uganda Population-Based HIV Impact Assessment (UPHIA) was conducted between August 2016 and March 2017 to measure the status of Uganda’s national HIV response. UPHIA offered household-based HIV counseling and testing, with the return of results. The survey team visited over 12,000 households to collect this information. In 2020, a second UPHIA was launched by the Ministry of Health to assess the country’s progress towards HIV epidemic control. The survey was conducted over 10,000 household interviews.
We store UPHIA samples collected from the UPHIA 2020 and UPHIA 2025 surveys.
Remnant plasma specimens stored in the National Biorepository with the micronutrient panel for the samples. The characteristic variables include age, gender, geographical location (district), and micronutrient biomarker test results. The samples have been collected from the outpatient department of selected Government hospitals geographically across the whole Country.
Send a specimen request inquiry to [email protected]
Requests for specimen use undergo review to confirm approval
Competing requests for scarce resources shall be considered on a first-come, first-served basis.
Considerations during the review shall include;
Potential impact of the proposed research
Whether the research use is appropriate to the nature and purpose of the repository
Availability of the specimens of a specific type
Adequacy of the research design and funding
Public Health benefits
Risks of the proposed research, legal and ethical considerations
5. Researchers are required to obtain Research Ethics Committee approval for the research use of specimens and/or data.
6. Research ethics approval is obtained and filed prior to specimen or data distribution.
Burden of sickle cell trait and disease in the Uganda Sickle Surveillance Study (US3): a cross-sectional study. Lancet Global Health. https://pubmed.ncbi.nlm.nih.gov/26833239/
Emergence and spread of a SARS-CoV-2 lineage A variant (A. 23.1) with altered spike protein in Uganda. Nature Microbiology. https://www.nature.com/articles/s41564-021-00933-9
Emergence of acquired HIV drug resistance among individuals receiving dolutegravir-based antiretroviral therapy in Uganda: a National Laboratory-Based Survey 2023. Open Forum Infectious Diseases. https://academic.oup.com/ofid/article/12/12/ofaf679/8315262
Role of a regulatory and governance framework in human biological materials and data sharing in National Biobanks: Case studies from Biobank Integrating Platform, Taiwan and the National Biorepository, Uganda. Wellcome Open Research. https://pmc.ncbi.nlm.nih.gov/articles/PMC7479498/
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